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Article

Reducing hyperactivated BAP1 attenuates mutant ASXL1-driven myeloid malignancies in human haematopoietic cells.

Cancer letters - 28 Oct 2021

Bai Jiaojiao, Chen Zizhen, Chen Chao, Zhang Mingying, Zhang Yuhui, Song Junzhe, Yuan Jiajia, Jiang Xiao, Xing Wen, Yang Jing, Bai Jie, Zhou Yuan

Abstract excerpt

Additional sex combs-like 1 (ASXL1) is frequently mutated in a variety of myeloid malignancies, resulting in expression of a C-terminal-truncated ASXL1 protein that confers gain of function on the ASXL1-BAP1 deubiquitinase (DUB) complex. Several studies have reported that hyperactivity of BRCA-1-associated protein 1 (BAP1) in deubiquitinating mono-ubiquitinated histone H2AK119 is one of the critical molecular...

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PMID: 34186160
DOI: 10.1016/j.canlet.2021.06.019

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Reducing hyperactivated BAP1 attenuates mutant ASXL1-driven myeloid malignancies in human haematopoietic cells.PMID 34186160Read ↗

Human ASXL1-Mutant Hematopoiesis Is Driven by a Truncated Protein Associated with Aberrant Deubiquitination of H2AK119.Semantic proximity Read ↗

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.Semantic proximity Read ↗

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Modeling ASXL1 mutation revealed impaired hematopoiesis caused by derepression of p16Ink4a through aberrant PRC1-mediated histone modification.Semantic proximity Read ↗

[Role of ASXL1 mutation in myeloid malignancies].Semantic proximity Read ↗

The distinct biological implications of Asxl1 mutation and its roles in leukemogenesis revealed by a knock-in mouse model.Semantic proximity Read ↗

Loss of the Tumor Suppressor BAP1 Causes Myeloid TransformationSemantic proximity Read ↗

Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex.Semantic proximity Read ↗

The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in CancerSemantic proximity Read ↗

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo.Semantic proximity Read ↗

Generation and Characterization of Induced Pluripotent Stem Cells Carrying An ASXL1 Mutation.Semantic proximity Read ↗

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