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Article

BAP1 as a guardian of genome stability: implications in human cancer.

Experimental & molecular medicine - 1 Apr 2023

Kwon Jongbum, Lee Daye, Lee Shin-Ai

Abstract excerpt

BAP1 is a ubiquitin C-terminal hydrolase domain-containing deubiquitinase with a wide array of biological activities. Studies in which advanced sequencing technologies were used have uncovered a link between BAP1 and human cancer. Somatic and germline mutations of the BAP1 gene have been identified in multiple human cancers, with a particularly high frequency in mesothelioma, uveal melanoma and clear cell renal...

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Identifiers

PMID: 37009801
DOI: 10.1038/s12276-023-00979-1
PMCID: PMC10167335

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