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Article

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo.

Leukemia - 1 Aug 2018

Guo Ying, Yang Hui, Chen Shi, Zhang Peng, Li Rong, Nimer Stephen D, Harbour J William, Xu Mingjiang, Yang Feng-Chun

Abstract excerpt

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Topics

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Share to Cell Transformation, Neoplastic
Share to Gene Expression Regulation, Leukemic
Share to Leukemia, Experimental
Share to Leukemia, Myeloid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Repressor Proteins

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Source

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Identifiers

PMID: 29743720
DOI: 10.1038/s41375-018-0126-9
PMCID: PMC6168429

Genes

ASXL1
BAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo.PMID 29743720Read ↗

The role of ASXL1 in hematopoiesis and myeloid malignanciesSemantic proximity Read ↗

Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.Semantic proximity Read ↗

Aberrant histone modifications induced by mutant ASXL1 in myeloid neoplasmsSemantic proximity Read ↗

Reducing hyperactivated BAP1 attenuates mutant ASXL1-driven myeloid malignancies in human haematopoietic cells.Semantic proximity Read ↗

Epigenetic regulation by ASXL1 in myeloid malignancies.Semantic proximity Read ↗

Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases.Semantic proximity Read ↗

Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice.Semantic proximity Read ↗

Loss of the Tumor Suppressor BAP1 Causes Myeloid TransformationSemantic proximity Read ↗

Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex.Semantic proximity Read ↗

[Role of ASXL1 mutation in myeloid malignancies].Semantic proximity Read ↗

Frequent ASXL1 mutations in children and young adults with chronic myeloid leukemia.Semantic proximity Read ↗

[Pathophysiology of hematological malignancies associated with ASXL1 mutations].Semantic proximity Read ↗

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