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Article

Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2017

Yu Lei, Lutz Michael W, Farfel Jose M, Wilson Robert S, Burns Daniel K, Saunders Ann M, De Jager Philip L, Barnes Lisa L, Schneider Julie A, Bennett David A

Abstract excerpt

INTRODUCTION: The study investigated the role of neuropathologies in the relationship between TOMM40 '523 genotype and late-life cognitive decline. METHODS: Participants were community-dwelling older persons who had annual cognitive assessments and brain autopsies after death. Genotyping used DNA from peripheral blood or postmortem brain tissue. Linear mixed models assessed the extent to which the association of...

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Identifiers

PMID: 28624335
DOI: 10.1016/j.jalz.2017.05.002
PMCID: PMC5723540

Genes

TOMM40

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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