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Article

Methylene blue protects against TDP-43 and FUS neuronal toxicity in C. elegans and D. rerio.

PloS one - 1 Jan 2012

Vaccaro Alexandra, Patten Shunmoogum A, Ciura Sorana, Maios Claudia, Therrien Martine, Drapeau Pierre, Kabashi Edor, Parker J Alex

Abstract excerpt

The DNA/RNA-binding proteins TDP-43 and FUS are found in protein aggregates in a growing number of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and related dementia, but little is known about the neurotoxic mechanisms. We have generated Caenorhabditis elegans and zebrafish animal models expressing mutant human TDP-43 (A315T or G348C) or FUS (S57Δ or R521H) that reflect certain aspects...

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Identifiers

PMID: 22848727
DOI: 10.1371/journal.pone.0042117
PMCID: PMC3407135

Genes

FUS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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