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Article

Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo.

Neurobiology of disease - 1 Jul 2013

Vaccaro Alexandra, Patten Shunmoogum A, Aggad Dina, Julien Carl, Maios Claudia, Kabashi Edor, Drapeau Pierre, Parker J Alex

Abstract excerpt

C. elegans and D. rerio expressing mutant TAR DNA Binding Protein 43 (TDP-43) are powerful in vivo animal models for the genetics and pharmacology of amyotrophic lateral sclerosis (ALS). Using these small-animal models of ALS, we previously identified methylene blue (MB) as a potent suppressor of...

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PMID: 23567652
DOI: 10.1016/j.nbd.2013.03.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23567652-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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