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Article

Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery.

Annual review of genetics - 1 Jan 1998

Skibbens R V, Hieter P

Abstract excerpt

Whether we consider the division of the simplest unicellular organisms into two daughter cells or the generation of haploid gametes by the most complex eukaryotes, no two processes secure the continuance of life more than the proper replication and segregation of the genetic material. The cell cycle, marked in part by the periodic rise and fall of cyclin-dependent kinase (CDK) activities, is the means by which...

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PMID: 9928483
DOI: 10.1146/annurev.genet.32.1.307

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