Article
Kinesins klp5(+) and klp6(+) are required for normal chromosome movement in mitosis.
Journal of cell science - 1 Mar 2002
West Robert R, Malmstrom Terra, McIntosh J Richard
Abstract excerpt
Proper mitotic chromosome segregation requires dynamic interactions between spindle microtubules and kinetochores. Here we demonstrate that two related fission yeast kinesins, klp5(+) and klp6(+), are required for normal chromosome segregation in mitosis. Null mutants frequently lack a normal metaphase chromosome alignment. Chromosome pairs move back and forth along the spindle for an extended period prior to...
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