Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The C-terminal half of Saccharomyces cerevisiae Mad1p mediates spindle checkpoint function, chromosome transmission fidelity and CEN association.

Genetics - 1 Jun 2005

Kastenmayer James P, Lee Marina S, Hong Andrew L, Spencer Forrest A, Basrai Munira A

Abstract excerpt

The evolutionarily conserved spindle checkpoint is a key mechanism ensuring high-fidelity chromosome transmission. The checkpoint monitors attachment between kinetochores and mitotic spindles and the tension between sister kinetochores. In the absence of proper attachment or tension, the spindle checkpoint mediates cell cycle arrest prior to anaphase. Saccharomyces cerevisiae Mad1p is required for the spindle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphase
Share to Chromatin Immunoprecipitation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes

Share to Genes, Reporter

Share to Genome, Fungal

Share to Kinetochores

Share to Nocodazole

Share to Spindle Apparatus

Source

Open in PubMed Open full text

Identifiers

PMID: 15802513
DOI: 10.1534/genetics.105.041426
PMCID: PMC1450390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The C-terminal half of Saccharomyces cerevisiae Mad1p mediates spindle checkpoint function, chromosome transmission fidelity and CEN association.PMID 15802513Read ↗

Cyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint.Semantic proximity Read ↗

Mph1 kinetochore localization is crucial and upstream in the hierarchy of spindle assembly checkpoint protein recruitment to kinetochores.Semantic proximity Read ↗

A mitotic role for Mad1 beyond the spindle checkpoint.Semantic proximity Read ↗

Mitotic checkpoint proteins Mad1 and Mad2 - structural and functional relationship with implication in genetic diseases.Semantic proximity Read ↗

Mad1's ability to interact with Mad2 is essential to regulate and monitor meiotic synapsis in C. elegans.Semantic proximity Read ↗

Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint.Semantic proximity Read ↗

Drosophila CENP-A mutations cause a BubR1-dependent early mitotic delay without normal localization of kinetochore components.Semantic proximity Read ↗

Lesions in many different spindle components activate the spindle checkpoint in the budding yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast Dam1p has a role at the kinetochore in assembly of the mitotic spindle.Semantic proximity Read ↗

Distinct chromosome segregation roles for spindle checkpoint proteins.Semantic proximity Read ↗

The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint.Semantic proximity Read ↗

The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.