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Article

Functional characterization of the α5(Asn398) variant associated with risk for nicotine dependence in the α3β4α5 nicotinic receptor.

Molecular pharmacology - 1 Nov 2011

Li Ping, McCollum Megan, Bracamontes John, Steinbach Joe Henry, Akk Gustav

Abstract excerpt

Smoking is a major cause for premature death. Work aimed at identifying genetic factors that contribute to nicotine addiction has revealed several single nucleotide polymorphisms (SNPs) that are linked to smoking-related behaviors such as nicotine dependence and level of smoking. One of these SNPs leads to an aspartic acid-to-asparagine substitution in the nicotinic receptor α5 subunit at amino acid position 398...

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Identifiers

PMID: 21856741
DOI: 10.1124/mol.111.073841
PMCID: PMC3198915

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