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Article

Functional differences between ATP-gated human and rat P2X3 receptors are caused by critical residues of the intracellular C-terminal domain.

Journal of neurochemistry - 1 Aug 2012

Sundukova Mayya, Vilotti Sandra, Abbate Rita, Fabbretti Elsa, Nistri Andrea

Abstract excerpt

ATP-activated P2X3 receptors of sensory ganglion neurons contribute to pain transduction and are involved in chronic pain signaling. Although highly homologous (97%) in rat and human species, it is unclear whether P2X3 receptors have identical function. Studying human and rat P2X3 receptors expressed in patch-clamped human embryonic kidney (HEK) cells, we investigated the role of non-conserved tyrosine residues...

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PMID: 22639984
DOI: 10.1111/j.1471-4159.2012.07810.x

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Functional differences between ATP-gated human and rat P2X3 receptors are caused by critical residues of the intracellular C-terminal domain.PMID 22639984Read ↗

Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory sites.Semantic proximity Read ↗

Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor.Semantic proximity Read ↗

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Conserved lysin and arginin residues in the extracellular loop of P2X(3) receptors are involved in agonist binding.Semantic proximity Read ↗

Agonist antagonist interactions at the rapidly desensitizing P2X3 receptor.Semantic proximity Read ↗

Identification of amino acids within the P2X2 receptor C-terminus that regulate desensitization.Semantic proximity Read ↗

Identification of residues in the first transmembrane domain of the P2X7 that regulates receptor trafficking, sensitization, and dye uptake function.Semantic proximity Read ↗

Heteromultimerization modulates P2X receptor functions through participating extracellular and C-terminal subdomains.Semantic proximity Read ↗

Participation of the Lys313-Ile333 sequence of the purinergic P2X4 receptor in agonist binding and transduction of signals to the channel gate.Semantic proximity Read ↗

Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening.Semantic proximity Read ↗

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