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Article

MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.

Neurobiology of aging - 1 Mar 2013

Colom-Cadena Martí, Gelpi Ellen, Martí María J, Charif Sara, Dols-Icardo Oriol, Blesa Rafael, Clarimón Jordi, Lleó Alberto

Abstract excerpt

The microtubule-associated protein tau (MAPT) H1 haplotype has been identified as a genetic risk factor for synucleinopathies. However, whether it modulates tau or α-synuclein pathology remains unknown. Our aim was to investigate the relationship between MAPT haplotypes and pathologic aggregates of tau and α-synuclein in pathologically confirmed cases of dementia with Lewy bodies (DLB). Twenty-two cases...

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Source

Identifiers

PMID: 22819391
DOI: 10.1016/j.neurobiolaging.2012.06.015

Genes

MAPT
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.PMID 22819391Read ↗

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