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Article

The MAPT H1 haplotype is associated with tangle-predominant dementia.

Acta neuropathologica - 1 Nov 2012

Santa-Maria Ismael, Haggiagi Aya, Liu Xinmin, Wasserscheid Jessica, Nelson Peter T, Dewar Ken, Clark Lorraine N, Crary John F

Abstract excerpt

Tangle-predominant dementia (TPD) patients exhibit cognitive decline that is clinically similar to early to moderate-stage Alzheimer disease (AD), yet autopsy reveals neurofibrillary tangles in the medial temporal lobe composed of the microtubule-associated protein tau without significant amyloid...

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Source

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Identifiers

PMID: 22802095
DOI: 10.1007/s00401-012-1017-1
PMCID: PMC3608475

Genes

MAPT
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22802095-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The MAPT H1 haplotype is associated with tangle-predominant dementia.PMID 22802095Read ↗

The role of MAPT sequence variation in mechanisms of disease susceptibility.Semantic proximity Read ↗

Disentangling the role of the tau gene locus in sporadic tauopathies.Semantic proximity Read ↗

Genetic analysis of MAPT haplotype diversity in frontotemporal dementia.Semantic proximity Read ↗

Tangle diseases and the tau haplotypes.Semantic proximity Read ↗

MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.Semantic proximity Read ↗

The H1c haplotype at the MAPT locus is associated with Alzheimer's disease.Semantic proximity Read ↗

Genetic Architecture of MAPT Gene Region in Parkinson Disease SubtypesSemantic proximity Read ↗

MAPT haplotype H1G is associated with increased risk of dementia with Lewy bodies.Semantic proximity Read ↗

Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levelsSemantic proximity Read ↗

Association of MAPT haplotype-tagging SNPs with sporadic Parkinson's disease.Semantic proximity Read ↗

Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue.Semantic proximity Read ↗

Dementia risk in Parkinson disease: disentangling the role of MAPT haplotypes.Semantic proximity Read ↗

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