Article
Dementia risk in Parkinson disease: disentangling the role of MAPT haplotypes.
Archives of neurology - 1 Mar 2011
Setó-Salvia Núria, Clarimón Jordi, Pagonabarraga Javier, Pascual-Sedano Berta, Campolongo Antonia, Combarros Onofre, Mateo Jose Ignacio, Regaña Daniel, Martínez-Corral Merce, Marquié Marta, Alcolea Daniel, Suárez-Calvet Marc, Molina-Porcel Laura, Dols Oriol, Gómez-Isla Teresa, Blesa Rafael, Lleó Alberto, Kulisevsky Jaime
Abstract excerpt
BACKGROUND: Dementia in Parkinson disease (PD) causes nursing home placement, caregiver distress, higher health care burden, and increased mortality. OBJECTIVE: To determine whether the microtubule-associated protein tau (MAPT) H1 haplotype and MAPT subhaplotypes play a role in the risk of PD and Parkinson disease-dementia (PDD) complex. DESIGN: Case-control genetic analysis. SETTING: Movement Disorders and...
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