MAPT haplotype H1G is associated with increased risk of dementia with Lewy bodies.

doi:10.1016/j.jalz.2016.05.002

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Article

MAPT haplotype H1G is associated with increased risk of dementia with Lewy bodies.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2016

Labbé Catherine, Heckman Michael G, Lorenzo-Betancor Oswaldo, Soto-Ortolaza Alexandra I, Walton Ronald L, Murray Melissa E, Allen Mariet, Uitti Ryan J, Wszolek Zbigniew K, Smith Glenn E, Kantarci Kejal, Knopman David S, Lowe Val J, Jack Clifford R, Ertekin-Taner Nilüfer, Hassan Anhar, Savica Rodolfo, Petersen Ronald C, Parisi Joseph E, Maraganore Demetrius M, Graff-Radford Neill R, Ferman Tanis J, Boeve Bradley F, Dickson Dennis W, Ross Owen A

Abstract excerpt

INTRODUCTION: The MAPT H1 haplotype has been associated with several neurodegenerative diseases. We were interested in exploring the role of MAPT haplotypic variation in risk of dementia with Lewy bodies (DLB). METHOD: We genotyped six MAPT haplotype tagging SNPs and screened 431 clinical DLB cases, 347 pathologically defined high-likelihood DLB cases, and 1049 controls. RESULT: We performed haplotypic...

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PMID: 27287057
DOI: 10.1016/j.jalz.2016.05.002
PMCID: PMC5143206

Genes

MAPT

Variants

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