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Article

Disentangling the role of the tau gene locus in sporadic tauopathies.

Current Alzheimer research - 1 Dec 2010

Vandrovcova J, Anaya F, Kay V, Lees A, Hardy J, de Silva R

Abstract excerpt

Fibrillar aggregates of abnormally hyperphosphorylated tau protein are the major component of the pathological entities, including intraneuronal neurofibrillary tangles that define the broad class of late-onset neurodegenerative disorders called the tauopathies. Mutations in the tau gene (MAPT) causing familial frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) confirm that tau protein...

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Source

Identifiers

PMID: 20704554
DOI: 10.2174/156720510793611619

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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