Article
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease.
Human molecular genetics - 15 Aug 2005
Myers A J, Kaleem M, Marlowe L, Pittman A M, Lees A J, Fung H C, Duckworth J, Leung D, Gibson A, Morris C M, de Silva R, Hardy J
Abstract excerpt
Although it is clear that microtubule associated protein tau (MAPT) is involved in Alzheimer's disease (AD) pathology, it has not been clear whether it is involved genetically. We have recently examined the MAPT locus in progressive supranuclear palsy and found that a haplotype (H1c) on the background of the well-described H1 clade is associated with PSP. Here we report that the same haplotype is associated with...
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