Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults.

PloS one - 1 Jan 2016

Valenca Guilherme T, Srivastava Gyan P, Oliveira-Filho Jamary, White Charles C, Yu Lei, Schneider Julie A, Buchman Aron S, Shulman Joshua M, Bennett David A, De Jager Philip L

Abstract excerpt

BACKGROUND AND OBJECTIVE: Recently, we have shown that the Parkinson's disease (PD) susceptibility locus MAPT (microtubule associated protein tau) is associated with parkinsonism in older adults without a clinical diagnosis of PD. In this study, we investigated the relationship between parkinsonian signs and MAPT transcripts by assessing the effect of MAPT haplotypes on alternative splicing and expression levels...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Parkinson Disease

Share to Parkinsonian Disorders

Share to Protein Isoforms

Share to Quantitative Trait, Heritable

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27458716
DOI: 10.1371/journal.pone.0157452
PMCID: PMC4961370

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults.PMID 27458716Read ↗

Genetic Architecture of MAPT Gene Region in Parkinson Disease SubtypesSemantic proximity Read ↗

Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease.Semantic proximity Read ↗

Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue.Semantic proximity Read ↗

Haplotypes and gene expression implicate the MAPT region for Parkinson disease: the GenePD Study.Semantic proximity Read ↗

Tau haplotypes regulate transcription and are associated with Parkinson's disease.Semantic proximity Read ↗

Haplotype-specific expression of exon 10 at the human MAPT locus.Semantic proximity Read ↗

The role of MAPT sequence variation in mechanisms of disease susceptibility.Semantic proximity Read ↗

The MAPT H1 haplotype is associated with tangle-predominant dementia.Semantic proximity Read ↗

Full sequencing and haplotype analysis of MAPT in Parkinson's disease and rapid eye movement sleep behavior disorder.Semantic proximity Read ↗

Dementia risk in Parkinson disease: disentangling the role of MAPT haplotypes.Semantic proximity Read ↗

The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts.Semantic proximity Read ↗

MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.