Article
The role of tau in the pathological process and clinical expression of Huntington's disease.
Brain : a journal of neurology - 1 Jul 2015
Vuono Romina, Winder-Rhodes Sophie, de Silva Rohan, Cisbani Giulia, Drouin-Ouellet Janelle, Spillantini Maria G, Cicchetti Francesca, Barker Roger A
Abstract excerpt
Huntington's disease is a neurodegenerative disorder caused by an abnormal CAG repeat expansion within exon 1 of the huntingtin gene HTT. While several genetic modifiers, distinct from the Huntington's disease locus itself, have been identified as being linked to the clinical expression and progression of Huntington's disease, the exact molecular mechanisms driving its pathogenic cascade and clinical features,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.