Article
Tau and MAPT genetics in tauopathies and synucleinopathies.
Parkinsonism & related disorders - 1 Sept 2021
Leveille Etienne, Ross Owen A, Gan-Or Ziv
Abstract excerpt
MAPT encodes the microtubule-associated protein tau, which is the main component of neurofibrillary tangles (NFTs) and found in other protein aggregates. These aggregates are among the pathological hallmarks of primary tauopathies such as frontotemporal dementia (FTD). Abnormal tau can also be observed in secondary tauopathies such as Alzheimer's disease (AD) and synucleinopathies such as Parkinson's disease...
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