An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.

doi:10.1136/jnnp-2011-301413

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Article

An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.

Journal of neurology, neurosurgery, and psychiatry - 1 Apr 2012

Wider Christian, Ross Owen A, Nishioka Kenya, Heckman Michael G, Vilariño-Güell Carles, Jasinska-Myga Barbara, Erketin-Taner Nilufer, Rademakers Rosa, Graff-Radford Neill R, Mash Deborah C, Papapetropoulos Spiridon, Duara Ranjan, Uchikado Hirotake, Wszolek Zbigniew K, Farrer Matthew J, Dickson Dennis W

Abstract excerpt

PURPOSE: The study investigates the effects of genetic factors on the pathology of Alzheimer's disease (AD) and Lewy body (LB) diseases, including Parkinson's disease and dementia with Lewy bodies. METHODS: A multicentre autopsy series (762 brain samples) with AD, LB or vascular pathology was examined. The effects of the tau gene (MAPT) H1 haplotype, the H1 specific SNP rs242557, APOE and the α-synuclein gene...

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Identifiers

PMID: 22291217
DOI: 10.1136/jnnp-2011-301413
PMCID: PMC3623699

Genes

MAPT
APOE
SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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