Article
Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans.
The Journal of biological chemistry - 7 Sept 2012
Yuan Yiyuan, Kadiyala Chandra S, Ching Tsui-Ting, Hakimi Parvin, Saha Sudipto, Xu Hua, Yuan Chao, Mullangi Vennela, Wang Liwen, Fivenson Elayne, Hanson Richard W, Ewing Rob, Hsu Ao-Lin, Miyagi Masaru, Feng Zhaoyang
Abstract excerpt
Caloric restriction (CR) markedly extends life span and improves the health of a broad number of species. Energy metabolism fundamentally contributes to the beneficial effects of CR, but the underlying mechanisms that are responsible for this effect remain enigmatic. A multidisciplinary approach that involves quantitative proteomics, immunochemistry, metabolic quantification, and life span analysis was used to...
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