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Article

DAF-2 pathway mutations and food restriction in aging Caenorhabditis elegans differentially affect metabolism.

Neurobiology of aging - 1 May 2005

Houthoofd Koen, Braeckman Bart P, Lenaerts Isabelle, Brys Kristel, Matthijssens Filip, De Vreese Annemie, Van Eygen Sylvie, Vanfleteren Jacques R

Abstract excerpt

In Caenorhabditis elegans, metabolism and life expectancy respond to environmental cues of food availability and temperature. Several genes act in a neuroendocrine, DAF-2, insulin/IGF-1 receptor-like pathway in which reduced signaling affects metabolism and increases longevity. Here we describe the effect of reduced DAF-2 signaling on several parameters of metabolism including rates of oxygen consumption and heat...

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PMID: 15708444
DOI: 10.1016/j.neurobiolaging.2004.06.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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