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Article

Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans.

The Journal of biological chemistry - 15 Jan 2016

Yuan Yiyuan, Hakimi Parvin, Kao Clara, Kao Allison, Liu Ruifu, Janocha Allison, Boyd-Tressler Andrea, Hang Xi, Alhoraibi Hanna, Slater Erin, Xia Kevin, Cao Pengxiu, Shue Quinn, Ching Tsui-Ting, Hsu Ao-Lin, Erzurum Serpil C, Dubyak George R, Berger Nathan A, Hanson Richard W, Feng Zhaoyang

Abstract excerpt

Aging involves progressive loss of cellular function and integrity, presumably caused by accumulated stochastic damage to cells. Alterations in energy metabolism contribute to aging, but how energy metabolism changes with age, how these changes affect aging, and whether they can be modified to modulate aging remain unclear. In locomotory muscle of post-fertile Caenorhabditis elegans, we identified a progressive...

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PMID: 26631730
DOI: 10.1074/jbc.M115.691766
PMCID: PMC4714217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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