Article
Life-Span Extension by Axenic Dietary Restriction Is Independent of the Mitochondrial Unfolded Protein Response and Mitohormesis in Caenorhabditis elegans.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Oct 2017
Cai Huaihan, Rasulova Madina, Vandemeulebroucke Lieselot, Meagher Lea, Vlaeminck Caroline, Dhondt Ineke, Braeckman Bart P
Abstract excerpt
In Caenorhabditis elegans, a broad range of dietary restriction regimens extend life span to different degrees by separate or partially overlapping molecular pathways. One of these regimens, axenic dietary restriction, doubles the worm's life span but currently, almost nothing is known about the underlying molecular mechanism. Previous studies suggest that mitochondrial stress responses such as the mitochondrial...
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