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Article

Lithocholic acid phenocopies anti-ageing effects of calorie restriction.

Nature - 1 Jul 2025

Qu Qi, Chen Yan, Wang Yu, Long Shating, Wang Weiche, Yang Heng-Ye, Li Mengqi, Tian Xiao, Wei Xiaoyan, Liu Yan-Hui, Xu Shengrong, Zhang Cixiong, Zhu Mingxia, Lam Sin Man, Wu Jianfeng, Yun Chuyu, Chen Junjie, Xue Shengye, Zhang Baoding, Zheng Zhong-Zheng, Piao Hai-Long, Jiang Changtao, Guo Hao, Shui Guanghou, Deng Xianming, Zhang Chen-Song, Lin Sheng-Cai

Abstract excerpt

Calorie restriction (CR) is a dietary intervention used to promote health and longevity1,2. CR causes various metabolic changes in both the production and the circulation of metabolites1; however, it remains unclear which altered metabolites account for the physiological benefits of CR. Here we use metabolomics to analyse metabolites that exhibit changes in abundance during CR and perform subsequent functional...

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Identifiers

PMID: 39695227
DOI: 10.1038/s41586-024-08329-5
PMCID: PMC12222012

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