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Article

The genetics of caloric restriction in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 27 Oct 1998

Lakowski B, Hekimi S

Abstract excerpt

Low caloric intake (caloric restriction) can lengthen the life span of a wide range of animals and possibly even of humans. To understand better how caloric restriction lengthens life span, we used genetic methods and criteria to investigate its mechanism of action in the nematode Caenorhabditis elegans. Mutations in many genes (eat genes) result in partial starvation of the worm by disrupting the function of the...

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Identifiers

PMID: 9789046
DOI: 10.1073/pnas.95.22.13091
PMCID: PMC23719

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