Is life span extension in single gene long-lived Caenorhabditis elegans mutants due to hypometabolism?

Abstract excerpt

The nematode C. elegans is widely used in aging research largely because of the identification of numerous gene mutations that significantly increase worm longevity. While model organisms such as C. elegans can provide important insights into aging it is also important to consider the limitations of these systems. For example, ectothermic (poikilothermic) organisms are able to tolerate a much larger metabolic...

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