Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional differences exist between TNFα promoters encoding the common -237G SNP and the rarer HLA-B*5701-linked A variant.

PloS one - 1 Jan 2012

Simpson Peter D, Moysi Eirini, Wicks Kate, Sudan Kritika, Rowland-Jones Sarah L, McMichael Andrew J, Knight Julian, Gillespie Geraldine M

Abstract excerpt

A large body of functional and epidemiological evidence have previously illustrated the impact of specific MHC class I subtypes on clinical outcome during HIV-1 infection, and these observations have recently been re-iterated in genome wide association studies (GWAS). Yet because of the complexities surrounding GWAS-based approaches and the lack of knowledge relating to the identity of rarer single nucleotide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to HLA-B Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipopolysaccharides

Share to Luciferases

Share to Lymphocyte Activation

Share to Monocytes

Share to Solubility

Share to Tetradecanoylphorbol Acetate

Source

Open in PubMed Open full text

Identifiers

PMID: 22808100
DOI: 10.1371/journal.pone.0040100
PMCID: PMC3396654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional differences exist between TNFα promoters encoding the common -237G SNP and the rarer HLA-B*5701-linked A variant.PMID 22808100Read ↗

A TNF variant that associates with susceptibility to musculoskeletal disease modulates thyroid hormone receptor binding to control promoter activation.Semantic proximity Read ↗

Post-genomics and the neutral theory: variation and conservation in the tumor necrosis factor-alpha promoter.Semantic proximity Read ↗

TNF-alpha promoter single nucleotide polymorphisms are markers of human ancestry.Semantic proximity Read ↗

The role of HLA promoters in autoimmunity.Semantic proximity Read ↗

Novel genetic association of TNF-α-238 and PDCD1-7209 polymorphisms with long-term non-progressive HIV-1 infection.Semantic proximity Read ↗

Co-regulation of HIV control and cytomegalovirus pp65-specific IL-1β and TNF-α responses by genetic variants in the MHC region.Semantic proximity Read ↗

Residues in HLA class I that Account for Variation of the HIV Host Response Distinctly Modulate Interactions with TCR and KIRsSemantic proximity Read ↗

Allele-specific chromatin remodeling of the tumor necrosis factor-alpha promoter.Semantic proximity Read ↗

TNFA promoter alleles--frequencies and linkage with classical HLA genes in a South German Caucasian population.Semantic proximity Read ↗

Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10.Semantic proximity Read ↗

Effect of TNF-alpha genetic variants and CCR5 Delta 32 on the vulnerability to HIV-1 infection and disease progression in Caucasian Spaniards.Semantic proximity Read ↗

Primate TNF promoters reveal markers of phylogeny and evolution of innate immunity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.