A TNF variant that associates with susceptibility to musculoskeletal disease modulates thyroid hormone receptor binding to control promoter activation.

doi:10.1371/journal.pone.0076034

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Article

A TNF variant that associates with susceptibility to musculoskeletal disease modulates thyroid hormone receptor binding to control promoter activation.

PloS one - 1 Jan 2013

Kiss-Toth Endre, Harlock Edward, Lath Darren, Quertermous Thomas, Wilkinson J Mark

Abstract excerpt

Tumor necrosis factor (TNF) is a powerful pro-inflammatory cytokine and immuno-regulatory molecule, and modulates susceptibility to musculoskeletal diseases. Several meta-analyses and replicated association studies have implicated the minor 'A' variant within the TNF promoter single nucleotide polymorphism (SNP) rs361525 (-238A/G) as a risk allele in joint related disorders, including psoriatic and juvenile...

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Identifiers

PMID: 24069456
DOI: 10.1371/journal.pone.0076034
PMCID: PMC3777919

Genes

TNF
THRA
THRB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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