Article
Effect of TNF-alpha genetic variants and CCR5 Delta 32 on the vulnerability to HIV-1 infection and disease progression in Caucasian Spaniards.
BMC medical genetics - 26 Apr 2010
Veloso Sergi, Olona Montserrat, García Felipe, Domingo Pere, Alonso-Villaverde Carlos, Broch Montserrat, Peraire Joaquim, Viladés Consuelo, Plana Montserrat, Pedrol Enric, López-Dupla Miguel, Aguilar Carmen, Gutiérrez Mar, Leon Agathe, Tasias Mariona, Gatell Josep Ma, Richart Cristóbal, Vidal Francesc
Abstract excerpt
BACKGROUND: Tumor necrosis factor alpha (TNF-alpha) is thought to be involved in the various immunogenetic events that influence HIV-1 infection. METHODS: We aimed to determine whether carriage of the TNF-alpha-238G>A, -308G>A and -863 C>A gene promoter single nucleotide polymorphisms (SNP) and the CCR5 Delta 32 variant allele influence the risk of HIV-1 infection and disease progression in Caucasian Spaniards....
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