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Article

Primate TNF promoters reveal markers of phylogeny and evolution of innate immunity.

PloS one - 18 Jul 2007

Baena Andres, Mootnick Alan R, Falvo James V, Tsytskova Alla V, Ligeiro Filipa, Diop Ousmane M, Brieva Claudia, Gagneux Pascal, O'Brien Stephen J, Ryder Oliver A, Goldfeld Anne E

Abstract excerpt

BACKGROUND: Tumor necrosis factor (TNF) is a critical cytokine in the immune response whose transcriptional activation is controlled by a proximal promoter region that is highly conserved in mammals and, in particular, primates. Specific single nucleotide polymorphisms (SNPs) upstream of the proximal human TNF promoter have been identified, which are markers of human ancestry. METHODOLOGY/PRINCIPAL FINDINGS:...

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PMID: 17637837
DOI: 10.1371/journal.pone.0000621
PMCID: PMC1905939

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TNF

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