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Article

TNF-alpha promoter single nucleotide polymorphisms are markers of human ancestry.

Genes and immunity - 1 Dec 2002

Baena A, Leung J Y, Sullivan A D, Landires I, Vasquez-Luna N, Quiñones-Berrocal J, Fraser P A, Uko G P, Delgado J C, Clavijo O P, Thim S, Meshnick S R, Nyirenda T, Yunis E J, Goldfeld A E

Abstract excerpt

We present a map of single nucleotide polymorphisms (SNPs) in the human tumor necrosis factor (TNF)-alpha promoter based upon exploratory sequencing of 333 human TNF-alpha gene promoters from individuals of distinct ancestral backgrounds. We detect 10 TNF-alpha promoter SNPs that occur with distinct frequencies in populations of different ancestry. Consistent with these findings, we show that two TNF-alpha SNPs,...

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PMID: 12486607
DOI: 10.1038/sj.gene.6363898

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TNF

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Source receipt: pubmed, retrieved 7 Sept 2026.

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