Article
Co-regulation of HIV control and cytomegalovirus pp65-specific IL-1β and TNF-α responses by genetic variants in the MHC region.
PLoS pathogens - 1 Jul 2026
Ruijten Suzanne D E, Dos Santos Jéssica C, Rios-Vazquez Victoria, Navas Adriana, Maas Hanneke, Groenendijk Albert L, Blaauw Marc J T, van Eekeren Louise E, Vos Wilhelm A J W, Knoll Rainer, Kumar Gupta Manoj, Ter Horst Rob, Botey-Bataller Javier, van Unen Nienke, Li Yang, Aschenbrenner Anna C, Schultze Joachim L, Xu Cheng-Jian, Netea Mihai G, van der Ven Andre J A M, Matzaraki Vasiliki
Abstract excerpt
The spontaneous control of HIV infection in the absence of antiretroviral therapy, termed HIV control, is associated with genetic variation in the Major Histocompatibility Complex (MHC) locus. These variants are known to influence the immune response to HIV itself. However, people living with HIV are often co-infected with other pathogens that can also elicit immune responses, which might also be regulated by...
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