Article
Allele-specific chromatin remodeling of the tumor necrosis factor-alpha promoter.
Biochemical and biophysical research communications - 22 Dec 2006
Skoog Tiina, Hamsten Anders, Eriksson Per
Abstract excerpt
The -863 C/A polymorphism in the tumor necrosis factor-alpha (TNF-alpha) promoter has been suggested to influence TNF-alpha expression. Here we elucidated the molecular mechanisms underlying the allele-specific regulation of TNF-alpha gene expression under basal and LPS-stimulated conditions in THP-1 cells and in human primary macrophages. We show that the binding of two NF-kappaB complexes, the p50/p50 homodimer...
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