Article
Novel genetic association of TNF-α-238 and PDCD1-7209 polymorphisms with long-term non-progressive HIV-1 infection.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Oct 2013
Nasi Milena, Riva Agostino, Borghi Vanni, D'Amico Roberto, Del Giovane Cinzia, Casoli Claudio, Galli Massimo, Vicenzi Elisa, Gibellini Lara, De Biasi Sara, Clerici Mario, Mussini Cristina, Cossarizza Andrea, Pinti Marcello
Abstract excerpt
OBJECTIVES: About 2-5% of HIV-1-infected subjects, defined as long-term non-progressors (LTNPs), remain immunologically stable for a long time without treatment. The factors governing this condition are known only in part, and include genetic factors. Thus, we studied 20 polymorphisms of 15 genes encoding proinflammatory and immunoregulatory cytokines, chemokines and their receptors, genes involved in apoptosis,...
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