Article
Post-genomics and the neutral theory: variation and conservation in the tumor necrosis factor-alpha promoter.
Gene - 30 Dec 2000
Goldfeld A E, Leung J Y, Sawyer S A, Hartl D L
Abstract excerpt
In the post-genomics era, molecular evolutionary geneticists have come to possess the molecular, statistical, and computational tools for estimating the relative importance of selection and random genetic drift in virtually any gene in almost any organism. We have examined single-nucleotide polymorphisms (SNPs) and nucleotide divergence across a region of approximately 1 kb in the promoter of the human tumor...
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