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Article

Evolution of the multi-domain structures of virulence genes in the human malaria parasite, Plasmodium falciparum.

PLoS computational biology - 1 Jan 2012

Buckee Caroline O, Recker Mario

Abstract excerpt

The var gene family of Plasmodium falciparum encodes the immunodominant variant surface antigens PfEMP1. These highly polymorphic proteins are important virulence factors that mediate cytoadhesion to a variety of host tissues, causing sequestration of parasitized red blood cells in vital organs, including the brain or placenta. Acquisition of variant-specific antibodies correlates with protection against severe...

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Identifiers

PMID: 22511852
DOI: 10.1371/journal.pcbi.1002451
PMCID: PMC3325180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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