Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homology blocks of Plasmodium falciparum var genes and clinically distinct forms of severe malaria in a local population.

BMC microbiology - 6 Nov 2013

Rorick Mary M, Rask Thomas S, Baskerville Edward B, Day Karen P, Pascual Mercedes

Abstract excerpt

BACKGROUND: The primary target of the human immune response to the malaria parasite Plasmodium falciparum, P. falciparum erythrocyte membrane protein 1 (PfEMP1), is encoded by the members of the hyper-diverse var gene family. The parasite exhibits antigenic variation via mutually exclusive expression (switching) of the ~60 var genes within its genome. It is thought that different variants exhibit different host...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Variation
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Malaria, Falciparum

Share to Plasmodium falciparum

Share to Protozoan Proteins

Share to Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 24192078
DOI: 10.1186/1471-2180-13-244
PMCID: PMC3827005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homology blocks of Plasmodium falciparum var genes and clinically distinct forms of severe malaria in a local population.PMID 24192078Read ↗

Conservation of single amino-acid polymorphisms in <i>Plasmodium falciparum</i> erythrocyte membrane protein 1 and association with severe pathophysiologySemantic proximity Read ↗

Expression of specific <i>var</i> gene subtypes is differentially associated with severe malaria syndromesSemantic proximity Read ↗

Hypervariable antigen genes in malaria have ancient roots.Semantic proximity Read ↗

A molecular epidemiological study of var gene diversity to characterize the reservoir of Plasmodium falciparum in humans in Africa.Semantic proximity Read ↗

Genetic diversity of expressed Plasmodium falciparum var genes from Tanzanian children with severe malaria.Semantic proximity Read ↗

Meta-analysis of Plasmodium falciparum var Signatures Contributing to Severe Malaria in African Children and Indian Adults.Semantic proximity Read ↗

Plasmodium falciparum Erythrocyte Membrane Protein 1 Diversity in Seven Genomes – Divide and ConquerSemantic proximity Read ↗

Plasmodium falciparum expresses fewer var genes at lower levels during asymptomatic dry season infections than clinical malaria casesSemantic proximity Read ↗

Common virulence gene expression in adult first-time infected malaria patients and severe casesSemantic proximity Read ↗

A paradoxical population structure of <i>var</i> DBLα types in AfricaSemantic proximity Read ↗

Plasmodium falciparum var Gene Expression Homogeneity as a Marker of the Host-Parasite Relationship under Different Levels of Naturally Acquired Immunity to MalariaSemantic proximity Read ↗

<i>Plasmodium falciparum</i> expresses fewer <i>var</i> genes at lower levels during asymptomatic dry season infections than clinical malaria casesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.