Article
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.
American journal of human genetics - 4 Jan 2018
Medina-Gomez Carolina, Kemp John P, Trajanoska Katerina, Luan Jian'an, Chesi Alessandra, Ahluwalia Tarunveer S, Mook-Kanamori Dennis O, Ham Annelies, Hartwig Fernando P, Evans Daniel S, Joro Raimo, Nedeljkovic Ivana, Zheng Hou-Feng, Zhu Kun, Atalay Mustafa, Liu Ching-Ti, Nethander Maria, Broer Linda, Porleifsson Gudmar, Mullin Benjamin H, Handelman Samuel K, Nalls Mike A, Jessen Leon E, Heppe Denise H M, Richards J Brent, Wang Carol, Chawes Bo, Schraut Katharina E, Amin Najaf, Wareham Nick, Karasik David, Van der Velde Nathalie, Ikram M Arfan, Zemel Babette S, Zhou Yanhua, Carlsson Christian J, Liu Yongmei, McGuigan Fiona E, Boer Cindy G, Bønnelykke Klaus, Ralston Stuart H, Robbins John A, Walsh John P, Zillikens M Carola, Langenberg Claudia, Li-Gao Ruifang, Williams Frances M K, Harris Tamara B, Akesson Kristina, Jackson Rebecca D, Sigurdsson Gunnar, den Heijer Martin, van der Eerden Bram C J, van de Peppel Jeroen, Spector Timothy D, Pennell Craig, Horta Bernardo L, Felix Janine F, Zhao Jing Hua, Wilson Scott G, de Mutsert Renée, Bisgaard Hans, Styrkársdóttir Unnur, Jaddoe Vincent W, Orwoll Eric, Lakka Timo A, Scott Robert, Grant Struan F A, Lorentzon Mattias, van Duijn Cornelia M, Wilson James F, Stefansson Kari, Psaty Bruce M, Kiel Douglas P, Ohlsson Claes, Ntzani Evangelia, van Wijnen Andre J, Forgetta Vincenzo, Ghanbari Mohsen, Logan John G, Williams Graham R, Bassett J H Duncan, Croucher Peter I, Evangelou Evangelos, Uitterlinden Andre G, Ackert-Bicknell Cheryl L, Tobias Jonathan H, Evans David M, Rivadeneira Fernando
Abstract excerpt
Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children, total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar spine (LS) and femoral neck (FN) is used to diagnose osteoporosis. To date, genetic variants in more than 60 loci have been identified as associated with BMD. To investigate the genetic determinants of TB-BMD variation along the life...
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