Article

Genome Wide Association Metanalysis Of Skull Bone Mineral Density Identifies Loci Relevant For Osteoporosis And Craniosynostosis

2021-11-02

Abstract excerpt

Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of genes important to bone biology in general, and particularly for identifying components unique to intramembranous ossification, which cannot be captured at other skeletal sites. We assessed genetic determinants of SK-BMD in 43,800 individuals, identifying 59 genome-wide significant loci (4 novel), explaining 12.5% of its variance. P...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dbe8784f-c515-50c2-add4-aa55df651f60
DOI: 10.1101/2021.11.01.21265592

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome Wide Association Metanalysis Of Skull Bone Mineral Density Identifies Loci Relevant For Osteoporosis And CraniosynostosisDOI 10.1101/2021.11.01.21265592Read

Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed.Semantic proximity Read

Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.Semantic proximity Read

Joint Multi-Ancestry and Admixed GWAS Reveals the Complex Genetics behind Human Cranial Vault ShapeSemantic proximity Read

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.Semantic proximity Read

Molecular landscape of congenital vertebral malformations: recent discoveries and future directionsSemantic proximity Read

Digenic impairments of haploinsufficient genes in patients with craniosynostosis.Semantic proximity Read

Genomic structural variations link multiple genes to bone mineral density in a multi-ethnic cohort study: Louisiana osteoporosis studySemantic proximity Read

An Atlas of Human and Murine Genetic Influences on OsteoporosisSemantic proximity Read

KIAA1217 : A novel candidate gene associated with isolated and syndromic vertebral malformationsSemantic proximity Read

Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragilitySemantic proximity Read

De novo mutations in the BMP signaling pathway in lambdoid craniosynostosis.Semantic proximity Read

Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes.Semantic proximity Read