A Meta-Analysis of the Transferability of Bone Mineral Density Genetic Loci Associations From European to African Ancestry Populations.

doi:10.1002/jbmr.4220

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Article

A Meta-Analysis of the Transferability of Bone Mineral Density Genetic Loci Associations From European to African Ancestry Populations.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2021

Yau Michelle S, Kuipers Allison L, Price Ryan, Nicolas Aude, Tajuddin Salman M, Handelman Samuel K, Arbeeva Liubov, Chesi Alessandra, Hsu Yi-Hsiang, Liu Ching-Ti, Karasik David, Zemel Babette S, Grant Struan Fa, Jordan Joanne M, Jackson Rebecca D, Evans Michele K, Harris Tamara B, Zmuda Joseph M, Kiel Douglas P

Abstract excerpt

Genetic studies of bone mineral density (BMD) largely have been conducted in European populations. We therefore conducted a meta-analysis of six independent African ancestry cohorts to determine whether previously reported BMD loci identified in European populations were transferable to African ancestry populations. We included nearly 5000 individuals with both genetic data and assessments of BMD. Genotype...

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PMID: 33249669
DOI: 10.1002/jbmr.4220
PMCID: PMC8353846

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