Article
Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
PLoS genetics - 1 Jun 2014
Kemp John P, Medina-Gomez Carolina, Estrada Karol, St Pourcain Beate, Heppe Denise H M, Warrington Nicole M, Oei Ling, Ring Susan M, Kruithof Claudia J, Timpson Nicholas J, Wolber Lisa E, Reppe Sjur, Gautvik Kaare, Grundberg Elin, Ge Bing, van der Eerden Bram, van de Peppel Jeroen, Hibbs Matthew A, Ackert-Bicknell Cheryl L, Choi Kwangbom, Koller Daniel L, Econs Michael J, Williams Frances M K, Foroud Tatiana, Zillikens M Carola, Ohlsson Claes, Hofman Albert, Uitterlinden André G, Davey Smith George, Jaddoe Vincent W V, Tobias Jonathan H, Rivadeneira Fernando, Evans David M
Abstract excerpt
Heritability of bone mineral density (BMD) varies across skeletal sites, reflecting different relative contributions of genetic and environmental influences. To quantify the degree to which common genetic variants tag and environmental factors influence BMD, at different sites, we estimated the genetic (rg) and residual (re) correlations between BMD measured at the upper limbs (UL-BMD), lower limbs (LL-BMD) and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.