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Article

Osteoporosis Caused by Monoallelic Variant of WNT1 Gene in Four Pediatric Patients.

American journal of medical genetics. Part A - 1 May 2025

Wang Qiao, Liu Min, Cao Bing-Yan, Su Chang, Meng Xi, Ding Yuan, Ren Xiao-Ya, Gong Chun-Xiu

Abstract excerpt

Pediatric patients of autosomal dominant early onset osteoporosis conferred by heterozygous mutation in the WNT1 (OMIM: 615221) were rarely reported, and therapy in pediatrics is relatively inexperienced. The clinical and genotypic characteristics and treatment process of four children with osteoporosis caused by WNT1 monoallelic variation were analyzed. The patients admitted from June 2023 to January 2024. All...

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Source

Identifiers

PMID: 39780405
DOI: 10.1002/ajmg.a.63987

Genes

WNT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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