Article
Association analysis of WNT10B with bone mass and structure among individuals of African ancestry.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2009
Zmuda Joseph M, Yerges Laura M, Kammerer Candace M, Cauley Jane A, Wang Xiaojing, Nestlerode Cara S, Wheeler Victor W, Patrick Alan L, Bunker ClareAnn H, Moffett Susan P, Ferrell Robert E
Abstract excerpt
Wnts comprise a family of secreted growth factors that regulate the development and maintenance of many organs. Recently, Wnt10b was shown to stimulate osteoblastogenesis and bone formation in mice. To evaluate further the role of Wnt10b in bone health in humans, we performed bidirectional sequencing of approximately 8 kb of the WNT10B gene region in 192 individuals (96 African, 96 white) to identify single...
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