Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pseudoknot preorganization of the preQ1 class I riboswitch.

Journal of the American Chemical Society - 25 Jul 2012

Santner Tobias, Rieder Ulrike, Kreutz Christoph, Micura Ronald

Abstract excerpt

To explore folding and ligand recognition of metabolite-responsive RNAs is of major importance to comprehend gene regulation by riboswitches. Here, we demonstrate, using NMR spectroscopy, that the free aptamer of a preQ(1) class I riboswitch preorganizes into a pseudoknot fold in a temperature- and Mg(2+)-dependent manner. The preformed pseudoknot represents a structure that is close to the ligand-bound state and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aptamers, Nucleotide
Share to Base Pairing
Share to Ligands

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Magnesium

Share to Nuclear Magnetic Resonance, Biomolecular

Share to Nucleic Acid Conformation

Share to Riboswitch

Share to RNA, Bacterial

Source

Identifiers

PMID: 22775200
DOI: 10.1021/ja3049964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pseudoknot preorganization of the preQ1 class I riboswitch.PMID 22775200Read ↗

Evidence for pseudoknot formation of class I preQ1 riboswitch aptamers.Semantic proximity Read ↗

Tuning a riboswitch response through structural extension of a pseudoknot.Semantic proximity Read ↗

Nucleobase mutants of a bacterial preQ1-II riboswitch that uncouple metabolite sensing from gene regulation.Semantic proximity Read ↗

Two riboswitch classes that share a common ligand-binding fold show major differences in the ability to accommodate mutations.Semantic proximity Read ↗

A structural intermediate pre-organizes the add adenine riboswitch for ligand recognition.Semantic proximity Read ↗

Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain.Semantic proximity Read ↗

Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch.Semantic proximity Read ↗

In-silico studies on thermodynamics of ligand binding to Fluoride riboswitch aptamerSemantic proximity Read ↗

A kissing loop is important for btuB riboswitch ligand sensing and regulatory control.Semantic proximity Read ↗

High-throughput competitive binding assay for targeting RNA with small molecules: discovery of new PreQ <sub>1</sub> riboswitch ligandsSemantic proximity Read ↗

Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain.Semantic proximity Read ↗

NMR structure of a classical pseudoknot: interplay of single- and double-stranded RNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.