Pseudoknot preorganization of the preQ1 class I riboswitch.

doi:10.1021/ja3049964

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Article

Pseudoknot preorganization of the preQ1 class I riboswitch.

Journal of the American Chemical Society - 25 Jul 2012

Santner Tobias, Rieder Ulrike, Kreutz Christoph, Micura Ronald

Abstract excerpt

To explore folding and ligand recognition of metabolite-responsive RNAs is of major importance to comprehend gene regulation by riboswitches. Here, we demonstrate, using NMR spectroscopy, that the free aptamer of a preQ(1) class I riboswitch preorganizes into a pseudoknot fold in a temperature- and Mg(2+)-dependent manner. The preformed pseudoknot represents a structure that is close to the ligand-bound state and...

Topics

Aptamers, Nucleotide
Base Pairing
Base Sequence
Fusobacterium nucleatum
Ligands
Magnesium
Mutation
Nuclear Magnetic Resonance, Biomolecular
Nucleic Acid Conformation
RNA, Bacterial
Riboswitch
Temperature

Source

Open in PubMed

Identifiers

PMID: 22775200
DOI: 10.1021/ja3049964

Provenance

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