Article
Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch.
Nucleic acids research - 1 Jan 2007
Noeske Jonas, Buck Janina, Fürtig Boris, Nasiri Hamid R, Schwalbe Harald, Wöhnert Jens
Abstract excerpt
Riboswitches are highly structured elements in the 5'-untranslated regions (5'-UTRs) of messenger RNA that control gene expression by specifically binding to small metabolite molecules. They consist of an aptamer domain responsible for ligand binding and an expression platform. Ligand binding in the aptamer domain leads to conformational changes in the expression platform that result in transcription termination...
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