Article
Two riboswitch classes that share a common ligand-binding fold show major differences in the ability to accommodate mutations.
Nucleic acids research - 27 Nov 2024
Srivastava Yoshita, Akinyemi Olayinka, Rohe Tiana C, Pritchett Elizabeth M, Baker Cameron D, Sharma Akshara, Jenkins Jermaine L, Mathews David H, Wedekind Joseph E
Abstract excerpt
Riboswitches are structured RNAs that sense small molecules to control expression. Prequeuosine1 (preQ1)-sensing riboswitches comprise three classes (I, II and III) that adopt distinct folds. Despite this difference, class II and III riboswitches each use 10 identical nucleotides to bind the preQ1 metabolite. Previous class II studies showed high sensitivity to binding-pocket mutations, which reduced preQ1...
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