Article
A kissing loop is important for btuB riboswitch ligand sensing and regulatory control.
The Journal of biological chemistry - 30 Oct 2015
Lussier Antony, Bastet Laurène, Chauvier Adrien, Lafontaine Daniel A
Abstract excerpt
RNA-based genetic regulation is exemplified by metabolite-binding riboswitches that modulate gene expression through conformational changes. Crystal structures show that the Escherichia coli btuB riboswitch contains a kissing loop interaction that is in close proximity to the bound ligand. To analyze the role of the kissing loop interaction in the riboswitch regulatory mechanism, we used RNase H cleavage assays...
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