Article
Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients.
Breast cancer research : BCR - 1 Jan 2009
Schmidt Marjanka K, Tommiska Johanna, Broeks Annegien, van Leeuwen Flora E, Van't Veer Laura J, Pharoah Paul D P, Easton Douglas F, Shah Mitul, Humphreys Manjeet, Dörk Thilo, Reincke Scarlett A, Fagerholm Rainer, Blomqvist Carl, Nevanlinna Heli
Abstract excerpt
INTRODUCTION: Somatic inactivation of the TP53 gene in breast tumors is a marker for poor outcome, and breast cancer outcome might also be affected by germ-line variation in the TP53 gene or its regulators. We investigated the effects of the germ-line single nucleotide polymorphisms TP53 R72P (215G>C) and MDM2 SNP309 (-410T>G), and p53 protein expression in breast tumors on survival. METHODS: We pooled data from...
Topics
- Adult
- Aged
- Aged, 80 and over
- Breast Neoplasms
- Female
- Genes, p53
- Genotype
- Germ-Line Mutation
- Humans
- Immunohistochemistry